The Bacterial and Viral Agents of BRDC: Immune Evasion and Vaccine Developments

Bovine respiratory disease complex (BRDC) is a multifactorial of cattle which presents as bacterial and viral pneumonia. The causative agents BRDC work in synergy to suppress the host immune response increase colonisation lower tracts by pathogenic bacteria. Environmental stress and/or infection predispose secondary infections via suppression key innate adaptive mechanisms. This allows bacteria descend tract unchallenged. costliest among feedlot cattle, whilst vaccines exist for individual pathogens, there still lack evidence efficacy these uncertainty surrounding optimum timing delivery. review outlines immunosuppressive actions pathogens involved highlights issues development vaccinations against them.